Ighe Immunoglobulin heavy constant epsilon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igheprovided by MGI
Official Full Name: Immunoglobulin heavy constant epsilonprovided by MGI
Primary source: MGI:MGI:2685746
See related: Ensembl:ENSMUSG00000087642 IMGT/GENE-DB:IGHE; AllianceGenome:MGI:2685746
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm900
Summary: Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in B cell differentiation. Is active in cytoplasm. Orthologous to human IGHE (immunoglobulin heavy constant epsilon). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12 F1; 12 62.1 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (113232883..113236868, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (113269263..113273248, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.
Title: CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma.
TGF-beta secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-alpha and IgE.
Title: TGF-β secreted by human umbilical cord blood-derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF-α and IgE.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Other (1) 1 citation
Targeted (1) 1 citation

General gene information

Go to the top of the page Help

Markers

D12Mit19 (e-PCR), detects polymorphism
- UniSTS:116403

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in primary adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in type I hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IgE B cell receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of immunoglobulin complex, circulating	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.