Gale UDP-galactose 4'-epimerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Galeprovided by FlyBase
Official Full Name: UDP-galactose 4'-epimeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0035147
Locus tag: Dmel_CG12030
See related: AllianceGenome:FB:FBgn0035147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12030; dGALE; Dmel\CG12030; GALE
Summary: Enables UDP-N-acetylglucosamine 4-epimerase activity and UDP-glucose 4-epimerase activity. Involved in galactose metabolic process and larval lymph gland hemopoiesis. Predicted to be active in cytosol. Is expressed in several structures, including embryonic/larval circulatory system; extraembryonic structure; germ layer derivative; gut section; and yolk nucleus. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 61C8-61C8; 3-0.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (648555..651311)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (648555..651311)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results demonstrate that both UDP-gal and UDP-galNAc activities of dGALE are required for Drosophila survival, although distinct roles for each activity can be seen in specific windows of developmental time or in response to a galactose challenge.
Title: UDP-galactose 4'-epimerase activities toward UDP-Gal and UDP-GalNAc play different roles in the development of Drosophila melanogaster.
Drosophila with partial GALE loss survive in the absence of galactose but succumb in development if exposed to dietary galactose.
Title: UDP-galactose 4' epimerase (GALE) is essential for development of Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine 4-epimerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables UDP-glucose 4-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose 4-epimerase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose 4-epimerase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-D-galactose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-N-acetylgalactosamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-N-acetylglucosamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in galactose catabolic process via UDP-galactose	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose catabolic process via UDP-galactose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in galactose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: UDP-galactose 4'-epimerase

Names: CG12030-PA; CG12030-PB; Gale-PA; Gale-PB; UDP-gal 4' epimerase

NP_001246537.1

EC 5.1.3.2

EC 5.1.3.7

NP_612044.1

EC 5.1.3.2

EC 5.1.3.7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

648555..651311

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138200.4 → NP_612044.1 UDP-galactose 4'-epimerase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612044.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W0P5

UniProtKB/TrEMBL

M9ND19

Related

FBpp0072455

Conserved Domains (1) summary

cd05247
Location:5 → 341

UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
NM_001259608.2 → NP_001246537.1 UDP-galactose 4'-epimerase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246537.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W0P5

UniProtKB/TrEMBL

M9ND19

Conserved Domains (1) summary

cd05247
Location:5 → 341

UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs