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Rap1gap2 RAP1 GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 380711, updated on 2-Nov-2024

Summary

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Official Symbol
Rap1gap2provided by MGI
Official Full Name
RAP1 GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:3028623
See related
Ensembl:ENSMUSG00000038807 AllianceGenome:MGI:3028623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Garnl4; Gm1561; mKIAA1039
Summary
Enables GTPase activator activity. Acts upstream of or within negative regulation of neuron projection development. Located in cytoplasm and neuron projection. Is expressed in olfactory epithelium; pancreas; and telencephalon. Orthologous to human RAP1GAP2 (RAP1 GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cortex adult (RPKM 24.4), frontal lobe adult (RPKM 21.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Rap1gap2 in Genome Data Viewer
Location:
11 B5; 11 45.76 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74274182..74501796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74383356..74610915, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 1D Neighboring gene olfactory receptor family 1 subfamily D member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7014 Neighboring gene STARR-seq mESC enhancer starr_29957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:74369680-74369789 Neighboring gene STARR-seq mESC enhancer starr_29960 Neighboring gene STARR-seq mESC enhancer starr_29961 Neighboring gene STARR-seq mESC enhancer starr_29962 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene STARR-positive B cell enhancer ABC_E3971 Neighboring gene clustered mitochondria homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth. Imai K, et al. Gene, 2005 Dec 30. PMID 16169686
  2. Rap1gap2 regulates axon outgrowth in olfactory sensory neurons. Sadrian B, et al. Mol Cell Neurosci, 2012 Jul. PMID 22732430
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rap1gap2 overexpression limits neurite outgrowth and branching in Neuro-2a cells, and counteracts Rap1-induced augmentation of neurite outgrowth
    Title: Rap1gap2 regulates axon outgrowth in olfactory sensory neurons.
  2. Some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth. (mKIAA gene)
    Title: Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130388

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rap1 GTPase-activating protein 2
Names
GTPase activating RANGAP domain-like 4
GTPase-activating Rap/Ran-GAP domain-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015046.3 → NP_001015046.1  rap1 GTPase-activating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001015046.1

    Status: VALIDATED

    Source sequence(s)
    AK038834, AK147290, AL604065, AW457490, CJ106176
    Consensus CDS
    CCDS25032.1
    UniProtKB/Swiss-Prot
    Q3KNA3, Q3V3L0, Q5SVL6, Q80TL8
    UniProtKB/TrEMBL
    A0A171EBK8
    Related
    ENSMUSP00000099580.2, ENSMUST00000102521.9
    Conserved Domains (1) summary
    pfam02145
    Location:259 → 438
    Rap_GAP; Rap/ran-GAP

  2. NM_001364131.1 → NP_001351060.1  rap1 GTPase-activating protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL604065, AL627348
    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:287 → 466
    Rap_GAP; Rap/ran-GAP

  3. NM_001364132.1 → NP_001351061.1  rap1 GTPase-activating protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604065, AL627348, AL645971
    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:257 → 436
    Rap_GAP; Rap/ran-GAP

  4. NM_001401658.1 → NP_001388587.1  rap1 GTPase-activating protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL604065, AL627348

RNA

  1. NR_157089.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL604065, AL627348, AL645971
    Related
    ENSMUST00000047488.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74274182..74501796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533622.4 → XP_006533685.2  rap1 GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A171EBK8, A0A571BED8
    Related
    ENSMUSP00000158689.2, ENSMUST00000238457.2
    Conserved Domains (1) summary
    pfam02145
    Location:319 → 498
    Rap_GAP; Rap/ran-GAP

  2. XM_036156817.1 → XP_036012710.1  rap1 GTPase-activating protein 2 isoform X9

    Conserved Domains (1) summary
    pfam02145
    Location:210 → 389
    Rap_GAP; Rap/ran-GAP

  3. XM_036156816.1 → XP_036012709.1  rap1 GTPase-activating protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:225 → 404
    Rap_GAP; Rap/ran-GAP

  4. XM_030246102.2 → XP_030101962.1  rap1 GTPase-activating protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:244 → 423
    Rap_GAP; Rap/ran-GAP

  5. XM_006533624.3 → XP_006533687.1  rap1 GTPase-activating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:337 → 516
    Rap_GAP; Rap/ran-GAP

  6. XM_006533628.3 → XP_006533691.1  rap1 GTPase-activating protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A171EBK8
    Conserved Domains (1) summary
    pfam02145
    Location:256 → 435
    Rap_GAP; Rap/ran-GAP

  7. XM_006533629.3 → XP_006533692.1  rap1 GTPase-activating protein 2 isoform X6

    Conserved Domains (1) summary
    pfam02145
    Location:232 → 411
    Rap_GAP; Rap/ran-GAP

  8. XM_006533631.4 → XP_006533694.1  rap1 GTPase-activating protein 2 isoform X8

    Conserved Domains (1) summary
    pfam02145
    Location:217 → 396
    Rap_GAP; Rap/ran-GAP
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SVL6.1 GenPept UniProtKB/Swiss-Prot:Q5SVL6

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