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Shisa6 shisa family member 6 [ Mus musculus (house mouse) ]

Gene ID: 380702, updated on 2-Nov-2024

Summary

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Official Symbol
Shisa6provided by MGI
Official Full Name
shisa family member 6provided by MGI
Primary source
MGI:MGI:2685725
See related
Ensembl:ENSMUSG00000053930 AllianceGenome:MGI:2685725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm879; ckamp52
Summary
Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and testis. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 10.0), CNS E18 (RPKM 3.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Shisa6 in Genome Data Viewer
Location:
11 B3; 11 40.55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (66102551..66418715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (66211725..66527984, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger with KRAB and SCAN domains 6 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene STARR-seq mESC enhancer starr_29773 Neighboring gene STARR-seq mESC enhancer starr_29774 Neighboring gene predicted gene, 40027 Neighboring gene predicted gene 12296 Neighboring gene predicted gene, 45945 Neighboring gene STARR-seq mESC enhancer starr_29776 Neighboring gene STARR-seq mESC enhancer starr_29777 Neighboring gene predicted gene, 40028 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
    Title: AMPAR Auxiliary Protein SHISA6 Facilitates Purkinje Cell Synaptic Excitability and Procedural Memory Formation.
  2. This study proposes a generic mechanism of stem cell regulation in a facultative (or open) niche environment, with which different levels of a cell-autonomous inhibitor (SHISA6, in this case) generates heterogeneous resistance to widely distributed differentiation-promoting extracellular signaling, such as WNTs.
    Title: SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.
  3. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59.
    Title: Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
  4. Shisa6 prevents synaptically trapped AMPARs from depression at high-frequency synaptic transmission.
    Title: Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ionotropic glutamate receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in excitatory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of short-term neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in asymmetric, glutamatergic, excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendritic spine membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein shisa-6
Names
cysteine-knot AMPAR-modulating protein 52
cystine-knot AMPAR modulating protein of 52 kDa
protein shisa-6 homolog
shisa homolog 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034874.4 → NP_001030046.1  protein shisa-6 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001030046.1

    Status: VALIDATED

    Source sequence(s)
    AL663051, AL663083
    Consensus CDS
    CCDS24848.1
    UniProtKB/Swiss-Prot
    A0A172Q417, Q3UH99
    UniProtKB/TrEMBL
    F6VQZ6
    Related
    ENSMUSP00000071025.7, ENSMUST00000066679.7
    Conserved Domains (1) summary
    pfam13908
    Location:97 → 264
    Shisa; Wnt and FGF inhibitory regulator

  2. NM_001415764.1 → NP_001402693.1  protein shisa-6 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL663051, AL663083
    Related
    ENSMUSP00000120862.2, ENSMUST00000123454.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    66102551..66418715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246098.2 → XP_030101958.1  protein shisa-6 isoform X1

    UniProtKB/TrEMBL
    F6VQZ6
    Conserved Domains (1) summary
    pfam13908
    Location:97 → 276
    Shisa; Wnt and FGF inhibitory regulator

  2. XM_036156815.1 → XP_036012708.1  protein shisa-6 isoform X2

    UniProtKB/Swiss-Prot
    A0A172Q417, Q3UH99
    UniProtKB/TrEMBL
    F6VQZ6
    Conserved Domains (1) summary
    pfam13908
    Location:97 → 264
    Shisa; Wnt and FGF inhibitory regulator

  3. XM_006533619.5 → XP_006533682.1  protein shisa-6 isoform X1

    UniProtKB/TrEMBL
    F6VQZ6
    Conserved Domains (1) summary
    pfam13908
    Location:97 → 276
    Shisa; Wnt and FGF inhibitory regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UH99.1 GenPept UniProtKB/Swiss-Prot:Q3UH99

Gene LinkOut

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