KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: KIR2DS2provided by HGNC
Official Full Name: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2provided by HGNC
Primary source: HGNC:HGNC:6334
See related: MIM:604953
Gene type: protein coding
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NKAT5; CD158J; CD158b; p58 KIR
Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
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Genomic context

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Location:: 19q13.4

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General gene information

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Clone Names

MGC120018

General protein information

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Names: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2; NK receptor; natural killer associated transcript 5; natural killer cell inhibitory receptor; p58 killer cell inhibitory receptor KIR-K7a