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Lin28b lin-28 homolog B [ Mus musculus (house mouse) ]

Gene ID: 380669, updated on 2-Nov-2024

Summary

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Official Symbol
Lin28bprovided by MGI
Official Full Name
lin-28 homolog Bprovided by MGI
Primary source
MGI:MGI:3584032
See related
Ensembl:ENSMUSG00000063804 AllianceGenome:MGI:3584032
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lin-28.2; 2810403D23Rik; D030047M17Rik
Summary
Predicted to enable mRNA binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in RNA metabolic process; positive regulation of miRNA catabolic process; and regulation of gene expression. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and lumbar dorsal root ganglion. Used to study neuroblastoma. Orthologous to human LIN28B (lin-28 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 3.2), liver E14 (RPKM 3.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Lin28b in Genome Data Viewer
Location:
10 B2; 10 23.5 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (45252713..45362410, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45376617..45486314, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15934 Neighboring gene popeye domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_26577 Neighboring gene blood vessel epicardial substance Neighboring gene STARR-seq mESC enhancer starr_26578 Neighboring gene STARR-seq mESC enhancer starr_26579 Neighboring gene predicted gene, 51827 Neighboring gene STARR-seq mESC enhancer starr_26582 Neighboring gene STARR-seq mESC enhancer starr_26583 Neighboring gene STARR-seq mESC enhancer starr_26584 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_26585 Neighboring gene HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 Neighboring gene STARR-seq mESC enhancer starr_26586

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lin28b regulates age-dependent differences in murine platelet function. Stolla MC, et al. Blood Adv, 2019 Jan 8. PMID 30622145, Free PMC Article
  2. Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2. Wu K, et al. J Cell Physiol, 2019 Dec. PMID 31066045
  3. Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation. Jaiswal A, et al. Inflammation, 2020 Oct. PMID 32458348
  4. LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. Madison BB, et al. Genes Dev, 2013 Oct 15. PMID 24142874, Free PMC Article
  5. Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Beachy SH, et al. Blood, 2012 Aug 2. PMID 22723554, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
    Title: The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium.
  2. Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
    Title: Lin28b delays vasculature aging by reducing platelet-derived growth factor-beta resistance in senescent vascular smooth muscle cells.
  3. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
    Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
  4. LIN28B induces a differentiation program through CDX2 in colon cancer.
    Title: LIN28B induces a differentiation program through CDX2 in colon cancer.
  5. Lin28 paralogs regulate lung branching morphogenesis.
    Title: Lin28 paralogs regulate lung branching morphogenesis.
  6. Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
    Title: Lin28B Regulates Angiotensin II-Mediated Let-7c/miR-99a MicroRNA Formation Consequently Affecting Macrophage Polarization and Allergic Inflammation.
  7. LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
    Title: LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling.
  8. A B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to let-7 gene expression.
    Title: An ontogenetic switch drives the positive and negative selection of B cells.
  9. lin28B is a crucial modulator determining the fate of transplanted mesenchymal stem cells by regulating IGF-2-associated pathways and thereby enhancing their protective effects against AD
    Title: Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.
  10. The Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19(-/-) adult mice.
    Title: Lin28b controls a neonatal to adult switch in B cell positive selection.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA destabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of primary miRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of miRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in pre-miRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein lin-28 homolog B
Names
lin-28B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031772.2 → NP_001026942.1  protein lin-28 homolog B

    See identical proteins and their annotated locations for NP_001026942.1

    Status: VALIDATED

    Source sequence(s)
    BC089037, DQ127225
    Consensus CDS
    CCDS35895.1
    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Related
    ENSMUSP00000078361.7, ENSMUST00000079390.7
    Conserved Domains (2) summary
    PTZ00368
    Location:151 → 187
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:29 → 99
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    45252713..45362410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243182.4 → XP_011241484.1  protein lin-28 homolog B isoform X2

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:176 → 212
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:54 → 124
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  2. XM_011243180.4 → XP_011241482.1  protein lin-28 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011241482.1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:183 → 219
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:61 → 131
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  3. XM_036155874.1 → XP_036011767.1  protein lin-28 homolog B isoform X3

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:161 → 197
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:39 → 109
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  4. XM_011243183.4 → XP_011241485.1  protein lin-28 homolog B isoform X3

    See identical proteins and their annotated locations for XP_011241485.1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:161 → 197
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:39 → 109
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  5. XM_011243185.4 → XP_011241487.1  protein lin-28 homolog B isoform X3

    See identical proteins and their annotated locations for XP_011241487.1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:161 → 197
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:39 → 109
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  6. XM_011243186.3 → XP_011241488.1  protein lin-28 homolog B isoform X3

    See identical proteins and their annotated locations for XP_011241488.1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:161 → 197
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:39 → 109
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  7. XM_036155873.1 → XP_036011766.1  protein lin-28 homolog B isoform X1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:183 → 219
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:61 → 131
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  8. XM_011243187.3 → XP_011241489.1  protein lin-28 homolog B isoform X4

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:160 → 196
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:38 → 108
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  9. XM_011243188.1 → XP_011241490.1  protein lin-28 homolog B isoform X5

    See identical proteins and their annotated locations for XP_011241490.1

    UniProtKB/Swiss-Prot
    Q3UZC6, Q3V444, Q45KJ6
    Conserved Domains (2) summary
    PTZ00368
    Location:151 → 187
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    cd04458
    Location:29 → 99
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033152.1: Suppressed sequence

    Description
    NM_001033152.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q45KJ6.2 GenPept UniProtKB/Swiss-Prot:Q45KJ6

Gene LinkOut

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