U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hadh.L hydroxyacyl-CoA dehydrogenase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380594, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
hadh.L
Official Full Name
hydroxyacyl-CoA dehydrogenase L homeolog
Primary source
Xenbase:XB-GENE-1007284
Locus tag
XELAEV_18005624mg
See related
EnsemblRapid:ENSXLAG00005003852 AllianceGenome:Xenbase:XB-GENE-1007284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hadh; hadhsc
Summary
Predicted to enable 3-hydroxyacyl-CoA dehydrogenase activity and NAD+ binding activity. Predicted to act upstream of or within fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hadh.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (70678375..70692636)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (59867845..59882152)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene annexin A5 L homeolog Neighboring gene cytochrome P450 family 2 subfamily U member 1 L homeolog Neighboring gene lymphoid enhancer binding factor 1 L homeolog Neighboring gene protein ALP1-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC69125

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 3-hydroxyacyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
hydroxyacyl-CoA dehydrogenase L homeolog
Names
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
hydroxyacyl-Coenzyme A dehydrogenase
NP_001080900.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087431.1 → NP_001080900.1  hydroxyacyl-CoA dehydrogenase L homeolog

    See identical proteins and their annotated locations for NP_001080900.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056108
    UniProtKB/TrEMBL
    A0A974I3J2, Q7T0N8
    Related
    ENSXLAP00005011507.1, ENSXLAT00005011681.1
    Conserved Domains (3) summary
    COG1250
    Location:25 → 312
    FadB; 3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]
    pfam00725
    Location:215 → 312
    3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
    pfam02737
    Location:28 → 213
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    70678375..70692636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials