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dld.S dihydrolipoamide dehydrogenase S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380588, updated on 4-Nov-2024

Summary

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Official Symbol
dld.S
Official Full Name
dihydrolipoamide dehydrogenase S homeolog
Primary source
Xenbase:XB-GENE-982854
Locus tag
XELAEV_18021003mg
See related
EnsemblRapid:ENSXLAG00005008280 AllianceGenome:Xenbase:XB-GENE-982854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dld
Summary
Predicted to enable dihydrolipoyl dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be located in acrosomal vesicle; mitochondrion; and motile cilium. Predicted to be part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See dld.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (74022898..74039192)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (72613304..72629599)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26, member 3, gene 1 S homeolog Neighboring gene solute carrier family 26 member 3 S homeolog Neighboring gene laminin subunit beta 1 S homeolog Neighboring gene solute carrier family 2 member 13 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68940

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables dihydrolipoyl dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydrolipoamide dehydrogenase S homeolog
Names
dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)
NP_001080894.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087425.1 → NP_001080894.1  dihydrolipoamide dehydrogenase S homeolog

    See identical proteins and their annotated locations for NP_001080894.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056016
    UniProtKB/TrEMBL
    A0A974HR66, Q7T0W0
    Related
    ENSXLAP00005023924.1, ENSXLAT00005024632.1
    Conserved Domains (5) summary
    TIGR01350
    Location:43 → 508
    lipoamide_DH; dihydrolipoamide dehydrogenase
    pfam00070
    Location:215 → 288
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:390 → 496
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl10013
    Location:284 → 378
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    cl21454
    Location:26 → 78
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    74022898..74039192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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