prpf19.L pre-mRNA processing factor 19 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: prpf19.L
Official Full Name: pre-mRNA processing factor 19 L homeolog
Primary source: Xenbase:XB-GENE-6253412
Locus tag: XELAEV_18000054mg
See related: EnsemblRapid:ENSXLAG00005031230 AllianceGenome:Xenbase:XB-GENE-6253412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nmp200; prpf19
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within DNA repair; mRNA splicing, via spliceosome; and protein K63-linked ubiquitination. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Prp19 complex and U2-type catalytic step 1 spliceosome. Orthologous to human PRPF19 (pre-mRNA processing factor 19). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (64291689..64313000, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694896.1 (251220..272713)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IEA Inferred from Electronic Annotation more info
part_of U2-type catalytic step 1 spliceosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-mRNA processing factor 19 L homeolog

Names: PRP19/PSO4 pre-mRNA processing factor 19 homolog; nuclear matrix protein NMP200 related to splicing factor PRP19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087423.1 → NP_001080892.1 pre-mRNA processing factor 19 L homeolog

See identical proteins and their annotated locations for NP_001080892.1

Status: PROVISIONAL

Source sequence(s)

BC044093

UniProtKB/TrEMBL

A0A8J0PRA2, A0A974GZM7, A0AA97PZ83, Q7ZXW4

Related

ENSXLAP00005093607.1, ENSXLAT00005095303.1

Conserved Domains (5) summary

smart00504
Location:5 → 68

Ubox; Modified RING finger domain

COG2319
Location:224 → 504

WD40; WD40 repeat [General function prediction only]

cd00200
Location:223 → 503

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08606
Location:69 → 132

Prp19; Prp19/Pso4-like

sd00039
Location:224 → 262

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

64291689..64313000 complement

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GenBank, FASTA, Sequence Viewer (Graphics)