mcrs1.L microspherule protein 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mcrs1.L
Official Full Name: microspherule protein 1 L homeolog
Primary source: Xenbase:XB-GENE-5732662
Locus tag: XELAEV_18017758mg
See related: EnsemblRapid:ENSXLAG00005034895 AllianceGenome:Xenbase:XB-GENE-5732662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: p78; mcrs1; mcrs2; msp58
Summary: Predicted to enable G-quadruplex RNA binding activity. Acts upstream of or within otic vesicle development. Predicted to be part of Ino80 complex; MLL1 complex; and NSL complex. Is expressed in dermal system; ectoderm; mesenchyme; nervous system; and pharyngeal arch. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 3L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (83164725..83175983)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (67814286..67825555)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G-quadruplex RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Ino80 complex	IEA Inferred from Electronic Annotation more info
part_of MLL1 complex	IEA Inferred from Electronic Annotation more info
part_of NSL complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microspherule protein 1 L homeolog

Names: Microspherule-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087404.1 → NP_001080873.1 microspherule protein 1 L homeolog

See identical proteins and their annotated locations for NP_001080873.1

Status: PROVISIONAL

Source sequence(s)

BC056006

UniProtKB/TrEMBL

A0A974DDU0, Q7T0W8

Related

ENSXLAP00005104439.1, ENSXLAT00005106462.1

Conserved Domains (2) summary

cd00060
Location:336 → 436

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam13325
Location:125 → 322

MCRS_N; N-terminal region of micro-spherule protein