bmp7.L bone morphogenetic protein 7, gene 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: bmp7.L
Official Full Name: bone morphogenetic protein 7, gene 1 L homeolog
Primary source: Xenbase:XB-GENE-486018
Locus tag: XELAEV_18043497mg
See related: EnsemblRapid:ENSXLAG00005032648 AllianceGenome:Xenbase:XB-GENE-486018
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bmp7; op-1; bmp-7; bmp7.1; bmp7.1.L
Summary: Predicted to enable cytokine activity and growth factor activity. Predicted to act upstream of or within BMP signaling pathway. Predicted to be located in extracellular space. Is expressed in anatomical system; appendage; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (13829233..13881830, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (13740428..13793047, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
Title: Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus.
Bmp7 gradients steer nerve growth cones by a balancing act of limk1 and SSH on AD/cofilin.
Title: BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin.
BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Title: Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bone morphogenetic protein 7, gene 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087397.1 → NP_001080866.1 bone morphogenetic protein 7, gene 1 L homeolog

See identical proteins and their annotated locations for NP_001080866.1

Status: PROVISIONAL

Source sequence(s)

BC055959

UniProtKB/TrEMBL

A0A974H2X5, Q9YGH7

Related

ENSXLAP00005097874.1, ENSXLAT00005099681.1

Conserved Domains (2) summary

smart00204
Location:323 → 424

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:30 → 273

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

13829233..13881830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)