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vrk1.L VRK serine/threonine kinase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380541, updated on 4-Nov-2024

Summary

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Official Symbol
vrk1.L
Official Full Name
VRK serine/threonine kinase 1 L homeolog
Primary source
Xenbase:XB-GENE-1003802
Locus tag
XELAEV_18039592mg
See related
EnsemblRapid:ENSXLAG00005016693 AllianceGenome:Xenbase:XB-GENE-1003802
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
vrk1
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within peptidyl-serine phosphorylation and signal transduction. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vrk1.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (80157299..80175606)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (66721572..66739960)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108698739 Neighboring gene autophagy related 2B L homeolog Neighboring gene GSK3B interacting protein L homeolog Neighboring gene poly(A) polymerase alpha L homeolog Neighboring gene uncharacterized LOC108699546 Neighboring gene BCL11B, BAF complex component L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64390

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
VRK serine/threonine kinase 1 L homeolog; serine/threonine-protein kinase VRK1
Names
vaccinia related kinase 1 L homeolog
XP_018084157.1
XP_018084158.1
XP_018084159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    80157299..80175606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018228669.2 → XP_018084158.1  serine/threonine-protein kinase VRK1

    UniProtKB/TrEMBL
    A0A1L8F9N0, A0A974C853
    Related
    ENSXLAP00005049143.1, ENSXLAT00005050280.1

  2. XM_018228668.2 → XP_018084157.1  serine/threonine-protein kinase VRK1

    UniProtKB/TrEMBL
    A0A1L8F9N0, A0A974C853

  3. XM_018228670.2 → XP_018084159.1  serine/threonine-protein kinase VRK1

    UniProtKB/TrEMBL
    A0A1L8F9N0, A0A974C853

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001087378.1: Suppressed sequence

    Description
    NM_001087378.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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