ass1.L argininosuccinate synthase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ass1.L
Official Full Name: argininosuccinate synthase 1 L homeolog
Primary source: Xenbase:XB-GENE-17340606
See related: EnsemblRapid:ENSXLAG00005022116 AllianceGenome:Xenbase:XB-GENE-17340606
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ass; ass1; ass1.S
Summary: Predicted to enable argininosuccinate synthase activity. Predicted to act upstream of or within L-arginine biosynthetic process and urea cycle. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (8977702..9031749, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694837.1 (813190..835675)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-arginine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within argininosuccinate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urea cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: argininosuccinate synthase

Names: argininosuccinate synthase 1 S homeolog; argininosuccinate synthetase 1; arginosuccinate synthetase 1; citrulline--aspartate ligase

NP_001080795.1

EC 6.3.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087326.1 → NP_001080795.1 argininosuccinate synthase

See identical proteins and their annotated locations for NP_001080795.1

Status: PROVISIONAL

Source sequence(s)

BC046941

UniProtKB/Swiss-Prot

Q7ZWM4

Related

ENSXLAP00005065043.1, ENSXLAT00005066558.1

Conserved Domains (1) summary

cd01999
Location:8 → 399

Argininosuccinate_Synthase; Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In ...