ctnnb1.S catenin beta 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ctnnb1.S
Official Full Name: catenin beta 1 S homeolog
Primary source: Xenbase:XB-GENE-487204
Locus tag: XELAEV_18033202mg
See related: EnsemblRapid:ENSXLAG00005020354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ctnnb1; ctnnb1-a; ctnnb1-b; B-catenin
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Genomic context

Location:: chromosome: 6S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (46309541..46327339)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (45039112..45056918)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling
Title: WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.
Data support a mechanism in which maternal XSOX3 inhibits beta-catenin-mediated axis specification by repressing expression of Xnr5.
Title: The beta-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation.
data demonstrate a positive role for protein phosphatase 2A:B56epsilon in the Wnt/beta-catenin signaling pathway
Title: PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables alpha-catenin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catenin beta 1 S homeolog

Names: beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087280.1 → NP_001080749.1 catenin beta 1 S homeolog

See identical proteins and their annotated locations for NP_001080749.1

Status: PROVISIONAL

Source sequence(s)

BC045258

UniProtKB/Swiss-Prot

P26233

UniProtKB/TrEMBL

A0A974CJ64, Q7ZX35

Conserved Domains (3) summary

smart00185
Location:350 → 390

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:399 → 518

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:402 → 427

ARM; armadillo repeat [structural motif]