src.L SRC proto-oncogene, non-receptor tyrosine kinase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: src.L
Official Full Name: SRC proto-oncogene, non-receptor tyrosine kinase L homeolog
Primary source: Xenbase:XB-GENE-489824
Locus tag: XELAEV_18003086mg
See related: EnsemblRapid:ENSXLAG00005025285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: src; csrc; src1; src2; xsrc; c-src; src-1; src-a; src-b; src.S; pp60c-src; pp60v-src
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (38489755..38519777, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694832.1 (541097..571293, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The structural and functional competency of the UPIII-Src signaling system in membrane microdomains is strictly regulated during oocyte maturation.
Title: The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
The c-SRC1 gene maps to a long arm of one of the acrocentric chromosomes of the G category of Xenopus laevis.
Title: The c-SRC1 gene visualized by in situ hybridization on Xenopus laevis chromosomes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoclast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tyrosine-protein kinase Src-2

Names: SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; p60-Src-2; tyrosine protein kinase pp60-c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

NP_001080738.1

EC 2.7.10.2

XP_018096691.1

EC 2.7.10.2

XP_018096692.1

EC 2.7.10.2

XP_018096693.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087269.1 → NP_001080738.1 tyrosine-protein kinase Src-2

See identical proteins and their annotated locations for NP_001080738.1

Status: PROVISIONAL

Source sequence(s)

BC045134

UniProtKB/Swiss-Prot

P13115

UniProtKB/TrEMBL

Q7ZX73

Conserved Domains (4) summary

cd10365
Location:148 → 248

SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)

cd12008
Location:84 → 144

SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase

cd05071
Location:261 → 537

PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

pfam07714
Location:271 → 520

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

38489755..38519777 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)