cdk19.L cyclin-dependent kinase 19 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cdk19.L
Official Full Name: cyclin-dependent kinase 19 L homeolog
Primary source: Xenbase:XB-GENE-989178
Locus tag: XELAEV_18027188mg
See related: EnsemblRapid:ENSXLAG00005030952 AllianceGenome:Xenbase:XB-GENE-989178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: cdk-8; cdk11; cdk19; cdc2l6; cdk19.S
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (80612345..80703084)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (78399999..78498256)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase 19 L homeolog

Names: Cyclin-Dependent Kinase (67.8 kD) (cdk-8); cyclin-dependent kinase 19 S homeolog

NP_001080723.1

EC 2.7.11.22

XP_018117164.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087254.1 → NP_001080723.1 cyclin-dependent kinase 19 L homeolog

See identical proteins and their annotated locations for NP_001080723.1

Status: PROVISIONAL

Source sequence(s)

BC056076

UniProtKB/TrEMBL

A0A974CV17, A0A974CVS2, Q7T0R3

Related

ENSXLAP00005092868.1, ENSXLAT00005094552.1

Conserved Domains (2) summary

smart00220
Location:22 → 335

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07867
Location:18 → 335

STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6