gnb3.S guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gnb3.S
Official Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog
Primary source: Xenbase:XB-GENE-6256539
Locus tag: XELAEV_18036711mg
See related: EnsemblRapid:ENSXLAG00005022556 AllianceGenome:Xenbase:XB-GENE-6256539
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gnb3; cepg02; gnb3-a
Summary: Predicted to enable signaling receptor complex adaptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of heterotrimeric G-protein complex. Is expressed in visual system. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7S	NC_054384.1 (4565572..4588666, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7S	NC_030737.1 (4583493..4606472, complement)

Chromosome 7S - NC_054384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087217.1 → NP_001080686.1 guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog

See identical proteins and their annotated locations for NP_001080686.1

Status: PROVISIONAL

Source sequence(s)

BC056002

UniProtKB/TrEMBL

A0A974CB05, Q7SZU2

Related

ENSXLAP00005066396.1, ENSXLAT00005067920.1

Conserved Domains (4) summary

COG2319
Location:49 → 340

WD40; WD40 repeat [General function prediction only]

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

cl00494
Location:1 → 36

YbaB_DNA_bd; YbaB/EbfC DNA-binding family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054384.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

4565572..4588666 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041570382.1 → XP_041426316.1 guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1L9Z5, A0A974CB05

Conserved Domains (2) summary

cd00200
Location:12 → 304

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:22 → 59

7WD40; WD40 repeat [structural motif]