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impa1.L inositol(myo)-1(or 4)-monophosphatase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380327, updated on 4-Nov-2024

Summary

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Official Symbol
impa1.L
Official Full Name
inositol(myo)-1(or 4)-monophosphatase 1 L homeolog
Primary source
Xenbase:XB-GENE-17343389
Locus tag
XELAEV_18032140mg
See related
EnsemblRapid:ENSXLAG00005028671 AllianceGenome:Xenbase:XB-GENE-17343389
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
impa; impa1
Summary
Predicted to enable inositol monophosphate phosphatase activity and metal ion binding activity. Predicted to act upstream of or within inositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; and signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59 and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See impa1.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (133686503..133697957, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (124514715..124526172, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene peripheral myelin protein 2 L homeolog Neighboring gene E3 ubiquitin-protein ligase RNF31 Neighboring gene provisional ortholog of aquaporin 4 L homeolog Neighboring gene zinc finger AN1-type containing 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC64501

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol(myo)-1(or 4)-monophosphatase 1 L homeolog
NP_001080635.1
XP_018121776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087166.2 → NP_001080635.1  inositol(myo)-1(or 4)-monophosphatase 1 L homeolog

    See identical proteins and their annotated locations for NP_001080635.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054268
    UniProtKB/TrEMBL
    A0A974HGR6, B7ZRY8, Q7SYT9
    Related
    ENSXLAP00005085348.1, ENSXLAT00005087009.1
    Conserved Domains (1) summary
    cd01639
    Location:8 → 254
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    133686503..133697957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018266287.2 → XP_018121776.1  inositol(myo)-1(or 4)-monophosphatase 1 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0VH38, B7ZRY8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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