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dok4.L docking protein 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380322, updated on 4-Nov-2024

Summary

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Official Symbol
dok4.L
Official Full Name
docking protein 4 L homeolog
Primary source
Xenbase:XB-GENE-948699
Locus tag
XELAEV_18022856mg
See related
EnsemblRapid:ENSXLAG00005015461 AllianceGenome:Xenbase:XB-GENE-948699
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dok4
Summary
Predicted to act upstream of or within Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Orthologous to human DOK4 (docking protein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dok4.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (70677335..70701543)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (65437064..65461445)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene zona pellucida protein D L homeolog Neighboring gene adhesion G protein-coupled receptor G1 L homeolog Neighboring gene coiled-coil domain containing 102A L homeolog Neighboring gene protein kinase C delta type-like Neighboring gene coenzyme Q9 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53599

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
docking protein 4 L homeolog
Names
downstream of tyrosine kinase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087161.1 → NP_001080630.1  docking protein 4 L homeolog

    See identical proteins and their annotated locations for NP_001080630.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044121
    UniProtKB/TrEMBL
    A0A974D4W9, Q7ZXT9
    Related
    ENSXLAP00005045417.1, ENSXLAT00005046516.1
    Conserved Domains (3) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    pfam00169
    Location:8 → 112
    PH; PH domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    70677335..70701543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018256495.2 → XP_018111984.1  docking protein 4 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0UXR5, A0A974D4W9

  2. XM_041589167.1 → XP_041445101.1  docking protein 4 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MUG3, A0A974D4W9
    Conserved Domains (2) summary
    cd13164
    Location:125 → 227
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:15 → 105
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
Nucleotide Protein Strain
Heading Accession and Version

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