atp6v1b2.S ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atp6v1b2.S
Official Full Name: ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 S homeolog
Primary source: Xenbase:XB-GENE-941738
Locus tag: XELAEV_18020203mg
See related: EnsemblRapid:ENSXLAG00005016690 AllianceGenome:Xenbase:XB-GENE-941738
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: vha55; atp6v1b2
Summary: Predicted to enable ATP binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to act upstream of or within ATP metabolic process; proton transmembrane transport; and vacuolar acidification. Predicted to be located in apical plasma membrane; melanosome; and synaptic vesicle membrane. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy. Orthologous to human ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (23803331..23825095, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (23344801..23366680, complement)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vacuolar acidification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 S homeolog

Names: ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087144.1 → NP_001080613.1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 S homeolog

See identical proteins and their annotated locations for NP_001080613.1

Status: PROVISIONAL

Source sequence(s)

BC046738

UniProtKB/TrEMBL

A0A974D7D0, Q7ZTJ4

Related

ENSXLAP00005049294.1, ENSXLAT00005050435.1

Conserved Domains (4) summary

cd01135
Location:117 → 400

V_A-ATPase_B; V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi ...

TIGR01040
Location:45 → 508

V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

pfam00306
Location:416 → 502

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

pfam02874
Location:49 → 115

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

23803331..23825095 complement

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GenBank, FASTA, Sequence Viewer (Graphics)