zfp36l2.S ZFP36 ring finger protein-like 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: zfp36l2.S
Official Full Name: ZFP36 ring finger protein-like 2 S homeolog
Primary source: Xenbase:XB-GENE-6256550
Locus tag: XELAEV_18028735mg
See related: AllianceGenome:Xenbase:XB-GENE-6256550
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: c3h-3; XC3H-3; XC3H-3b; zfp36l2; zfp36l2-a; zfp36l2-b
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-independent decay and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Is expressed in ectoderm; mesenchyme; nervous system; pharyngeal arch; and urinary system. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (20130932..20135302, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (20180000..20184372, complement)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 3'-UTR-mediated mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to glucocorticoid stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within definitive hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of mitotic cell cycle phase transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pronephros development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of mRNA stability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somatic stem cell division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mRNA decay activator protein ZFP36L2-A

Names: CCCH zinc finger protein 3-A; Zinc finger protein 36, C3H1 type-like 2-A; zinc finger protein 36, C3H type-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087141.1 → NP_001080610.1 mRNA decay activator protein ZFP36L2-A

See identical proteins and their annotated locations for NP_001080610.1

Status: PROVISIONAL

Source sequence(s)

BC044086

UniProtKB/Swiss-Prot

Q5XH52, Q7ZXW9, Q805B4, Q9W673

UniProtKB/TrEMBL

A0A974CU29, A0A974HH46

Conserved Domains (2) summary

pfam00642
Location:132 → 157

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

pfam04553
Location:3 → 110

Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

20130932..20135302 complement

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GenBank, FASTA, Sequence Viewer (Graphics)