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pkm.L pyruvate kinase M1/2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380274, updated on 17-Aug-2024

Summary

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Official Symbol
pkm.L
Official Full Name
pyruvate kinase M1/2 L homeolog
Primary source
Xenbase:XB-GENE-17331006
Locus tag
XELAEV_18018020mg
See related
EnsemblRapid:ENSXLAG00005029654
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pk; pk3; pkm; cthbp
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Genomic context

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Location:
chromosome: 3L
Exon count:
13
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (97685218..97706091, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (82374059..82394925, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene unconventional myosin-IXa Neighboring gene SUMO peptidase family member, NEDD8 specific L homeolog Neighboring gene poly(ADP-ribose) polymerase family member 6 L homeolog Neighboring gene ariadne RBR E3 ubiquitin protein ligase 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53388

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate kinase M1/2 L homeolog
Names
pyruvate kinase, muscle
NP_001080582.1
XP_018106217.1
XP_041440897.1
XP_041440898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087113.1 → NP_001080582.1  pyruvate kinase M1/2 L homeolog

    See identical proteins and their annotated locations for NP_001080582.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044007
    UniProtKB/TrEMBL
    A0A974DEB1, Q7ZY25
    Related
    ENSXLAP00005088742.1, ENSXLAT00005090411.1
    Conserved Domains (2) summary
    cd00288
    Location:38 → 526
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:39 → 523
    pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    97685218..97706091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018250728.2 → XP_018106217.1  pyruvate kinase M1/2 L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A1L8H000, A0A974DCH3, A0A974DEB1
    Related
    ENSXLAP00005088672.1, ENSXLAT00005090340.1

  2. XM_041584963.1 → XP_041440897.1  pyruvate kinase M1/2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MGQ5, A0A974DEB1
    Conserved Domains (1) summary
    cd00288
    Location:101 → 589
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

  3. XM_041584964.1 → XP_041440898.1  pyruvate kinase M1/2 L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1MHA0, A0A974DEB1
    Related
    ENSXLAP00005088610.1, ENSXLAT00005090279.1
    Conserved Domains (1) summary
    cd00288
    Location:101 → 589
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
Nucleotide Protein Strain
Heading Accession and Version

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