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rno rhinoceros [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38027, updated on 2-Nov-2024

Summary

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Official Symbol
rnoprovided by FlyBase
Official Full Name
rhinocerosprovided by FlyBase
Primary source
FLYBASE:FBgn0035106
Locus tag
Dmel_CG7036
See related
AllianceGenome:FB:FBgn0035106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7036; Dmel\CG7036
Summary
Involved in compound eye photoreceptor development. Located in nucleus. Is expressed in spermatozoon. Orthologous to several human genes including JADE3 (jade family PHD finger 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See rno in Genome Data Viewer
Location:
61B2-61B2; 3-1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (187207..199762, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (187207..199762, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene MAP kinase-specific phosphatase Neighboring gene Mitochondrial carrier homolog 1 Neighboring gene mrityu Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Farrell K, et al. Acta Neuropathol, 2022 Jan. PMID 34719765, Free PMC Article
  2. Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes. Platts AE, et al. Fly (Austin), 2009 Jul-Sep. PMID 19690466, Free PMC Article
  3. RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Sukhanova MJ, et al. Dev Biol, 2011 Nov 15. PMID 21920355, Free PMC Article
  4. Probing the boundaries of orthology: the unanticipated rapid evolution of Drosophila centrosomin. Eisman RC, et al. Genetics, 2013 Aug. PMID 23749319, Free PMC Article
  5. Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Steele L, et al. Dev Biol, 2009 Nov 1. PMID 19744473, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide association study and functional validation implicates JADE1 in tauopathy.
    Title: Genome-wide association study and functional validation implicates JADE1 in tauopathy.
  2. Data show that the differentiation delay phenotype is caused by decreased levels of different components of the EGFR signaling pathway in the absence of rbf and rno.
    Title: RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye.
  3. Data show that removal of transcriptional activation of dE2F1 partially restores Delta expression in rbf,rno mutant clones and suppresses differentiation defects, indicating that this differentiation function of RBF is mediated by regulation of dE2F1.
    Title: Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rhinoceros
Names
CG7036-PB
CG7036-PC
CG7036-PD
rno-PB
rno-PC
rno-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    187207..199762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259599.2 → NP_001246528.1  rhinoceros, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246528.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDD8, Q7YZH1, Q9W0U2
    Conserved Domains (5) summary
    COG5141
    Location:250 → 664
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15573
    Location:314 → 359
    PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
    cd15707
    Location:367 → 480
    ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
    pfam03153
    Location:2138 → 2295
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam10513
    Location:250 → 288
    EPL1; Enhancer of polycomb-like

  2. NM_206222.3 → NP_995944.1  rhinoceros, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995944.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDD8, Q7YZH1, Q9W0U2
    Conserved Domains (5) summary
    COG5141
    Location:250 → 664
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15573
    Location:314 → 359
    PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
    cd15707
    Location:367 → 480
    ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
    pfam03153
    Location:2138 → 2295
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam10513
    Location:250 → 288
    EPL1; Enhancer of polycomb-like

  3. NM_138163.2 → NP_612007.2  rhinoceros, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612007.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDD8, Q7YZH1, Q9W0U2
    Conserved Domains (5) summary
    COG5141
    Location:250 → 664
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15573
    Location:314 → 359
    PHD_JADE; PHD finger found in proteins Jade-1, Jade-2, Jade-3, and similar proteins
    cd15707
    Location:367 → 480
    ePHD_RNO; Extended PHD finger found in Drosophila melanogaster PHD finger protein rhinoceros (RNO) and similar proteins
    pfam03153
    Location:2138 → 2295
    TFIIA; Transcription factor IIA, alpha/beta subunit
    pfam10513
    Location:250 → 288
    EPL1; Enhancer of polycomb-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YZH1.1 Q7YZH1

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