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hnrnpk.S heterogeneous nuclear ribonucleoprotein K S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380255, updated on 4-Nov-2024

Summary

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Official Symbol
hnrnpk.S
Official Full Name
heterogeneous nuclear ribonucleoprotein K S homeolog
Primary source
Xenbase:XB-GENE-6253918
Locus tag
XELAEV_18010151mg
See related
EnsemblRapid:ENSXLAG00005012078 AllianceGenome:Xenbase:XB-GENE-6253918
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hnrpk; hnrnpk
Summary
Predicted to enable DNA binding activity and RNA binding activity. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Is expressed in anatomical system and primary germ layer. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hnrnpk.S in Genome Data Viewer
Location:
chromosome: 1S
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (124082986..124094218, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (109325400..109336993, complement)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 S homeolog Neighboring gene FERM domain containing 3 S homeolog Neighboring gene recQ-mediated genome instability protein 1-like Neighboring gene solute carrier family 28 member 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo. Hutchins EJ, et al. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27501755
  2. Phosphorylation of heterogeneous nuclear ribonucleoprotein K at an extracellular signal-regulated kinase phosphorylation site promotes neurofilament-medium protein expression and axon outgrowth in Xenopus. Hutchins EJ, et al. Neurosci Lett, 2015 Oct 21. PMID 26409787
  3. Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis. Liu Y, et al. J Neurosci, 2012 Mar 7. PMID 22399778, Free PMC Article
  4. A crucial role for hnRNP K in axon development in Xenopus laevis. Liu Y, et al. Development, 2008 Sep. PMID 18725517
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo has been described.
    Title: A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo.
  2. a previously unidentified function of phosphorylation at this phylogenetically conserved site and implicates hnRNPK as an intracellular molecular target of ERK-mediated signaling in axon outgrowth.
    Title: Phosphorylation of heterogeneous nuclear ribonucleoprotein K at an extracellular signal-regulated kinase phosphorylation site promotes neurofilament-medium protein expression and axon outgrowth in Xenopus.
  3. hnRNP K is essential for successful optic axon regeneration via a novel post-transcriptional regulatory pathway.
    Title: Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis.
  4. A crucial role is reported for hnrpk in axon development in Xenoops laevis.
    Title: A crucial role for hnRNP K in axon development in Xenopus laevis.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC53459

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein K S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087094.1 → NP_001080563.1  heterogeneous nuclear ribonucleoprotein K S homeolog

    See identical proteins and their annotated locations for NP_001080563.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044711
    UniProtKB/TrEMBL
    A0A974I191, Q7ZXK8, Q9PSI1
    Related
    ENSXLAP00005035377.1, ENSXLAT00005036270.1
    Conserved Domains (3) summary
    cd00105
    Location:322 → 385
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:119 → 183
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam08067
    Location:6 → 40
    ROKNT; ROKNT (NUC014) domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    124082986..124094218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018233808.2 → XP_018089297.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974I191, Q7ZXK8, Q9PSI1

  2. XM_018233813.2 → XP_018089302.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974I191, Q7ZXK8, Q9PSI1

  3. XM_018233820.2 → XP_018089309.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A974I191, Q7ZXK8, Q9PSI1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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