U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dhcr7.L 7-dehydrocholesterol reductase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380248, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
dhcr7.L
Official Full Name
7-dehydrocholesterol reductase L homeolog
Primary source
Xenbase:XB-GENE-920377
Locus tag
XELAEV_18021759mg
See related
EnsemblRapid:ENSXLAG00005019715
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dhcr7; 7-Dhcr; Xdhcr7
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dhcr7.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (3411501..3420570)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (3469064..3472065)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 member 5 L homeolog Neighboring gene neural EGFL like 1 L homeolog Neighboring gene U2 spliceosomal RNA Neighboring gene growth arrest specific 2 L homeolog Neighboring gene solute carrier family 17 member 6 L homeolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cholesterol homeostasis in development: the role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development. Tadjuidje E, et al. Dev Dyn, 2006 Aug. PMID 16752377
  2. Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase. Koide T, et al. Development, 2006 Jun. PMID 16687448
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system
    Title: Cholesterol homeostasis in development: the role of Xenopus 7-dehydrocholesterol reductase (Xdhcr7) in neural development.
  2. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos.
    Title: Negative regulation of Hedgehog signaling by the cholesterogenic enzyme 7-dehydrocholesterol reductase.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC64361

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 7-dehydrocholesterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brassinosteroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within organic hydroxy compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
7-dehydrocholesterol reductase L homeolog
NP_001080556.1
XP_041445100.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087087.1 → NP_001080556.1  7-dehydrocholesterol reductase L homeolog

    See identical proteins and their annotated locations for NP_001080556.1

    Status: PROVISIONAL

    Source sequence(s)
    BC054203
    UniProtKB/TrEMBL
    Q7SYZ9
    Related
    ENSXLAP00005057927.1, ENSXLAT00005059281.1
    Conserved Domains (1) summary
    cl21511
    Location:97 → 340
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    3411501..3420570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589166.1 → XP_041445100.1  7-dehydrocholesterol reductase L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8GIE0, A0A974D276, Q1WAJ9
    Related
    ENSXLAP00005057913.1, ENSXLAT00005059267.1
    Conserved Domains (1) summary
    cl21511
    Location:97 → 473
    PEMT; Phospholipid methyltransferase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.