pdgfra.L platelet derived growth factor receptor alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pdgfra.L
Official Full Name: platelet derived growth factor receptor alpha L homeolog
Primary source: Xenbase:XB-GENE-6072934
Locus tag: XELAEV_18005286mg
See related: EnsemblRapid:ENSXLAG00005006625 AllianceGenome:Xenbase:XB-GENE-6072934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: G37; pdgfr2; pdgfra; pdgfralpha
Summary: Predicted to enable several functions, including ATP binding activity; platelet-derived growth factor alpha-receptor activity; and platelet-derived growth factor binding activity. Predicted to act upstream of or within several processes, including embryonic cranial skeleton morphogenesis; platelet-derived growth factor receptor signaling pathway; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus and cilium. Predicted to be part of receptor complex. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (41756745..41782987)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (32511258..32537495)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: platelet-derived growth factor receptor alpha

Names: PDGF-R-alpha; PDGFR-alpha; alpha platelet-derived growth factor receptor; alpha-type platelet-derived growth factor receptor; platelet derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor, alpha polypeptide L homeolog

NP_001080553.1

EC 2.7.10.1

XP_018124661.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087084.1 → NP_001080553.1 platelet-derived growth factor receptor alpha precursor

See identical proteins and their annotated locations for NP_001080553.1

Status: PROVISIONAL

Source sequence(s)

BC043948

UniProtKB/Swiss-Prot

P26619

UniProtKB/TrEMBL

Q7ZY71

Related

ENSXLAP00005019681.1, ENSXLAT00005020031.1

Conserved Domains (6) summary

cd05859
Location:316 → 416

Ig4_PDGFR-alpha; Fourth immunoglobulin (Ig)-like domain of platelet-derived growth factor receptor (PDGFR) alpha

cd05861
Location:231 → 314

Ig1_PDGFR-alphabeta; Frst immunoglobulin (Ig)-like domain of platelet-derived growth factor (PDGF) receptors (R), alpha (CD140a), and beta (CD140b)

cd05105
Location:557 → 955

PTKc_PDGFR_alpha; Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha

smart00410
Location:229 → 313

IG_like; Immunoglobulin like

pfam07714
Location:595 → 953

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:419 → 511

Ig; Immunoglobulin domain