rgma.L repulsive guidance molecule BMP co-receptor a L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rgma.L
Official Full Name: repulsive guidance molecule BMP co-receptor a L homeolog
Primary source: Xenbase:XB-GENE-876355
Locus tag: XELAEV_18018383mg
See related: EnsemblRapid:ENSXLAG00005021315
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rgma
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (118644298..118677628, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (103219392..103253054, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the current study reveals a pleiotropic role of RGMa in early vertebrate embryonic brain in the spatial organization of axon tracts, pioneer axon guidance, and neural cell differentiation.
Title: Dual roles of the chemorepellent axon guidance molecule RGMa in establishing pioneering axon tracts and neural fate decisions in embryonic vertebrate forebrain.
We demonstrate that Neogenin and RGMa are required for establishing the morphology of deep layer cells in the neural plate throughout neurulation.
Title: Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity.
RGM A and neogenin have important functions during early neural development.
Title: Repulsive guidance molecule A (RGM A) and its receptor neogenin during neural and neural crest cell development of Xenopus laevis.
Partial knock down of RGMa confirms that this chemorepulsive ligand of neogenin acts in the same early forming dorsoventral brain pathway.
Title: Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: repulsive guidance molecule BMP co-receptor a L homeolog

Names: RGM domain family, member A; repulsive guidance molecule A; repulsive guidance molecule family member a L homeolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087083.1 → NP_001080552.1 repulsive guidance molecule BMP co-receptor a L homeolog precursor

See identical proteins and their annotated locations for NP_001080552.1

Status: PROVISIONAL

Source sequence(s)

BC045008

UniProtKB/TrEMBL

C0IPU7, Q7ZXG2

Conserved Domains (2) summary

pfam06534
Location:210 → 391

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:32 → 205

RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

118644298..118677628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)