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krt8.S keratin 8, gene 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380217, updated on 4-Nov-2024

Summary

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Official Symbol
krt8.S
Official Full Name
keratin 8, gene 1 S homeolog
Primary source
Xenbase:XB-GENE-876943
Locus tag
XELAEV_18016072mg
See related
EnsemblRapid:ENSXLAG00005035088 AllianceGenome:Xenbase:XB-GENE-876943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
CK1; XCK1; krt8; krt8.1; KERATIN8; krt8.1.S
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to act upstream of or within intermediate filament organization and keratinization. Predicted to be located in cytoplasm. Is expressed in dermal system and nervous system. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See krt8.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (139377405..139387153)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (130387826..130397547)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4B S homeolog Neighboring gene keratin 18, type I, gene 1 S homeolog Neighboring gene keratin 78, gene 9 S homeolog Neighboring gene keratin 78, gene 7 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of cDNA and amino acid sequence of a cytokeratin expressed in oocytes of Xenopus laevis. Franz JK, et al. Proc Natl Acad Sci U S A, 1986 Sep. PMID 2428034, Free PMC Article
  2. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC53564

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables structural constituent of skin epidermis IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intermediate filament organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin, type II cytoskeletal 8
Names
CK-8
K8
cytokeratin-8
keratin 8 S homeolog
keratin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087056.1 → NP_001080525.1  keratin, type II cytoskeletal 8

    See identical proteins and their annotated locations for NP_001080525.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044116
    UniProtKB/Swiss-Prot
    P08776
    UniProtKB/TrEMBL
    A0A974DLL6, Q7ZXU4
    Related
    ENSXLAP00005104839.1, ENSXLAT00005106880.1
    Conserved Domains (4) summary
    pfam00038
    Location:98 → 409
    Filament; Intermediate filament protein
    pfam16208
    Location:47 → 95
    Keratin_2_head; Keratin type II head
    cl19219
    Location:310 → 399
    DUF342; Protein of unknown function (DUF342)
    cl23887
    Location:271 → 344
    DUF4349; Domain of unknown function (DUF4349)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    139377405..139387153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08776.1 GenPept UniProtKB/Swiss-Prot:P08776

Gene LinkOut

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