capn1.L calpain 1, (mu/I) large subunit L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: capn1.L
Official Full Name: calpain 1, (mu/I) large subunit L homeolog
Primary source: Xenbase:XB-GENE-6540652
Locus tag: XELAEV_18022120mg
See related: EnsemblRapid:ENSXLAG00005018283 AllianceGenome:Xenbase:XB-GENE-6540652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: canp; mucl; capn1; canpl1; mucanp
Summary: Predicted to enable calcium ion binding activity and calcium-dependent cysteine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4L

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (23378474..23411087)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (21833762..21866500)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calpain 1, (mu/I) large subunit L homeolog

NP_001080485.1

EC 3.4.22.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087016.1 → NP_001080485.1 calpain 1, (mu/I) large subunit L homeolog

See identical proteins and their annotated locations for NP_001080485.1

Status: PROVISIONAL

Source sequence(s)

BC044317

UniProtKB/TrEMBL

A0A974D463, Q7ZXQ4

Related

ENSXLAP00005053981.1, ENSXLAT00005055155.1

Conserved Domains (4) summary

cd00051
Location:589 → 639

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00648
Location:56 → 352

Peptidase_C2; Calpain family cysteine protease

pfam01067
Location:366 → 518

Calpain_III; Calpain large subunit, domain III

cl08302
Location:622 → 704

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...