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gnb3.L guanine nucleotide binding protein (G protein), beta polypeptide 3 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 380144, updated on 4-Nov-2024

Summary

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Official Symbol
gnb3.L
Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 3 L homeolog
Primary source
Xenbase:XB-GENE-17344588
Locus tag
XELAEV_18034407mg
See related
EnsemblRapid:ENSXLAG00005029593 AllianceGenome:Xenbase:XB-GENE-17344588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gnb3-b
Summary
Predicted to enable signaling receptor complex adaptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of heterotrimeric G-protein complex. Is expressed in visual system. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; depressive disorder; familial hyperlipidemia; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gnb3.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (7413868..7436130, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (7440415..7462955, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1019 Neighboring gene olfactory receptor 2G3 Neighboring gene provisional ortholog of tumor protein p63 regulated 1 like L homeolog Neighboring gene G protein-coupled receptor 162 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC68852

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables signaling receptor complex adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide binding protein (G protein), beta polypeptide 3 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086983.1 → NP_001080452.1  guanine nucleotide binding protein (G protein), beta polypeptide 3 L homeolog

    See identical proteins and their annotated locations for NP_001080452.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055978
    UniProtKB/TrEMBL
    A0A974CB05, A0A974CEG1, Q7T0Y9
    Related
    ENSXLAP00005088468.1, ENSXLAT00005090133.1
    Conserved Domains (4) summary
    COG2319
    Location:49 → 340
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:48 → 340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:58 → 95
    7WD40; WD40 repeat [structural motif]
    cl00494
    Location:1 → 36
    YbaB_DNA_bd; YbaB/EbfC DNA-binding family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    7413868..7436130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials