hif1a.L hypoxia inducible factor 1 subunit alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hif1a.L
Official Full Name: hypoxia inducible factor 1 subunit alpha L homeolog
Primary source: Xenbase:XB-GENE-946628
Locus tag: XELAEV_18039792mg
See related: EnsemblRapid:ENSXLAG00005030589 AllianceGenome:Xenbase:XB-GENE-946628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hif1a; xhif1a; hif1alpha; hif-1alpha
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within cellular response to hypoxia and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is expressed in anatomical system and pharyngeal arch. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (93260738..93298830, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (78535357..78573794, complement)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hif-1alpha is a key regulator that integrates epithelial to mesenchymal transition and chemotaxis during migration of neural crest cells.
Title: The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.
HIF-1alpha-regulated nkx2.5 expression is required for heart development in Xenopus
Title: HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hypoxia inducible factor 1 subunit alpha L homeolog

Names: hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086980.1 → NP_001080449.1 hypoxia inducible factor 1 subunit alpha L homeolog

See identical proteins and their annotated locations for NP_001080449.1

Status: VALIDATED

Source sequence(s)

BC043769

UniProtKB/TrEMBL

A0A974C9G2, A5X382, Q6PI54

Related

ENSXLAP00005092035.1, ENSXLAT00005093719.1

Conserved Domains (5) summary

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:239 → 338

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam08778
Location:766 → 801

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam11413
Location:545 → 575

HIF-1; Hypoxia-inducible factor-1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

93260738..93298830 complement

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GenBank, FASTA, Sequence Viewer (Graphics)