atp2a1.S ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atp2a1.S
Official Full Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog
Primary source: Xenbase:XB-GENE-975120
Locus tag: XELAEV_18002200mg
See related: EnsemblRapid:ENSXLAG00005006041 AllianceGenome:Xenbase:XB-GENE-975120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: dar; atp2a; atp2b; atp2a1; atp2a2; serca1; serca2; ca-p60a; atp2a1.L
Summary: Predicted to enable ATP binding activity; ATP hydrolysis activity; and P-type calcium transporter activity. Predicted to act upstream of or within calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in sarcoplasmic reticulum membrane. Is expressed in ectoderm; mesoderm; and musculoskeletal system. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (116914125..116932118)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694820.1 (330170..343885, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atp2a2/serca2 is found in a larger subset of cells, but is not ubiquitous as reported in adults.
Title: Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog

Names: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 L homeolog; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Calcium ATPase at 60A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086935.1 → NP_001080404.1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog

See identical proteins and their annotated locations for NP_001080404.1

Status: PROVISIONAL

Source sequence(s)

BC044063

UniProtKB/TrEMBL

Q7ZXY6

Related

ENSXLAP00005018170.1, ENSXLAT00005018466.1

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

116914125..116932118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041577649.1 → XP_041433583.1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1LVP6

Related

ENSXLAP00005018200.1, ENSXLAT00005018496.1

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3