rnf8.S ring finger protein 8, E3 ubiquitin protein ligase S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rnf8.S
Official Full Name: ring finger protein 8, E3 ubiquitin protein ligase S homeolog
Primary source: Xenbase:XB-GENE-6254223
Locus tag: XELAEV_18028570mg
See related: EnsemblRapid:ENSXLAG00005017601 AllianceGenome:Xenbase:XB-GENE-6254223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rnf8; rnf8-a; rnf8-b
Summary: Predicted to enable several functions, including protein homodimerization activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to act upstream of or within several processes, including DNA metabolic process; chromatin remodeling; and protein polyubiquitination. Predicted to be located in chromosome, telomeric region; nucleus; and site of double-strand break. Predicted to be part of ubiquitin ligase complex. Orthologous to human RNF8 (ring finger protein 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (7140629..7150928)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (7150657..7160879)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair-dependent chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epigenetic regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within isotype switching	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein K6-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ionizing radiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within sperm DNA condensation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase rnf8-A

Names: E3 ubiquitin-protein ligase RNF8-A; RING finger protein 8 A; RING-type E3 ubiquitin transferase rnf8-A; ring finger protein (C3HC4 type) 8

NP_001080384.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086915.1 → NP_001080384.1 E3 ubiquitin-protein ligase rnf8-A

See identical proteins and their annotated locations for NP_001080384.1

Status: PROVISIONAL

Source sequence(s)

BC046256

UniProtKB/Swiss-Prot

Q7ZX20

UniProtKB/TrEMBL

A0A974HGY6

Related

ENSXLAP00005051975.1, ENSXLAT00005053137.1

Conserved Domains (5) summary

COG1716
Location:50 → 101

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

COG5200
Location:295 → 435

LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]

cd00162
Location:381 → 423

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00498
Location:30 → 100

FHA; FHA domain

pfam15619
Location:223 → 368

Lebercilin; Ciliary protein causing Leber congenital amaurosis disease