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gsb gooseberry [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38005, updated on 2-Nov-2024

Summary

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Official Symbol
gsbprovided by FlyBase
Official Full Name
gooseberryprovided by FlyBase
Primary source
FLYBASE:FBgn0001148
Locus tag
Dmel_CG3388
See related
AllianceGenome:FB:FBgn0001148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BSH-9; BSH9; BSH9c2; CG3388; Dmel\CG3388; Gsb; gsb-2; gsb-d; Gsb-d; GSB-D; gsb-distal; gsbBSH9; gsbd; l(2)01155; l(2)gsb
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of synaptic activity; salivary gland morphogenesis; and segment polarity determination. Located in cytoplasm and nucleus. Is expressed in several structures, including anlage in statu nascendi; anterior-posterior subdivision of organism; genital disc; germ layer; and neuroblasts. Human ortholog(s) of this gene implicated in Waardenburg syndrome (multiple); alveolar rhabdomyosarcoma; congenital myopathy 19; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3) and PAX7 (paired box 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See gsb in Genome Data Viewer
Location:
60F2-60F2; 2-107 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (25061964..25064643)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20949487..20952166)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Neuropeptide-like precursor 1 Neighboring gene gooseberry-neuro Neighboring gene transfer RNA:Alanine-CGC 1-1 Neighboring gene transfer RNA:Alanine-CGC 1-2 Neighboring gene goliath

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the local temperature in space and time around a developing Drosophila embryo in a microfluidic device. Lucchetta EM, et al. Lab Chip, 2006 Feb. PMID 16450026
  2. Analysis of the gooseberry locus in Drosophila embryos: gooseberry determines the cuticular pattern and activates gooseberry neuro. Gutjahr T, et al. Development, 1993 May. PMID 8375335
  3. Compatibility between enhancers and promoters determines the transcriptional specificity of gooseberry and gooseberry neuro in the Drosophila embryo. Li X, et al. EMBO J, 1994 Jan 15. PMID 8313885, Free PMC Article
  4. Cooperative dimerization of paired class homeo domains on DNA. Wilson D, et al. Genes Dev, 1993 Nov. PMID 7901121
  5. A GAL4 driver resource for developmental and behavioral studies on the larval CNS of Drosophila. Li HH, et al. Cell Rep, 2014 Aug 7. PMID 25088417

See all (234) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gsb and gsbn share overlapping functions in segmentation and the central nervous system.
    Title: Differential and redundant functions of gooseberry and gooseberry neuro in the central nervous system and segmentation of the Drosophila embryo.
  2. Data show that the gooseberry/gooseberry-neuro (gsb/gsb-n) transcription factor genes act to specify MP3 cell fate.
    Title: Formation and specification of a Drosophila dopaminergic precursor cell.
  3. This study demonstrated that the transcription factor gooseberry is essential for the sustained expression of synaptic homeostasis at the Drosophila NMJ.
    Title: Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in segment polarity determination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ventral cord development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
gooseberry
Names
CG3388-PA
Gooseberry-distal
gooseberry distal
gsb-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    25061964..25064643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079139.4 → NP_523863.1  gooseberry [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09082, Q9W0W4
    UniProtKB/TrEMBL
    B6IDY6, Q4V700
    Conserved Domains (2) summary
    smart00351
    Location:19 → 143
    PAX; Paired Box domain
    cd00086
    Location:186 → 243
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09082.1 P09082

Gene LinkOut

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