wipi2.L WD repeat domain, phosphoinositide interacting 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wipi2.L
Official Full Name: WD repeat domain, phosphoinositide interacting 2 L homeolog
Primary source: Xenbase:XB-GENE-6084336
Locus tag: XELAEV_18045038mg
See related: EnsemblRapid:ENSXLAG00005020694 AllianceGenome:Xenbase:XB-GENE-6084336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: wipi2
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to act upstream of or within cellular response to starvation and protein localization to phagophore assembly site. Predicted to be located in cytosol and phagophore assembly site membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (94771328..94810174)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (84191422..84230334)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy of mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nucleophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein lipidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to phagophore assembly site	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat domain phosphoinositide-interacting protein 2

Names: WIPI-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086850.1 → NP_001080319.1 WD repeat domain phosphoinositide-interacting protein 2

See identical proteins and their annotated locations for NP_001080319.1

Status: PROVISIONAL

Source sequence(s)

BC046705

UniProtKB/Swiss-Prot

Q7ZWU5

UniProtKB/TrEMBL

A0A974C084

Related

ENSXLAP00005060716.1, ENSXLAT00005062165.1

Conserved Domains (3) summary

COG2319
Location:21 → 272

WD40; WD40 repeat [General function prediction only]

sd00039
Location:188 → 228

7WD40; WD40 repeat [structural motif]

cl02567
Location:121 → 265

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...