ndufs1.L NADH:ubiquinone oxidoreductase core subunit S1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ndufs1.L
Official Full Name: NADH:ubiquinone oxidoreductase core subunit S1 L homeolog
Primary source: Xenbase:XB-GENE-961235
Locus tag: XELAEV_18044958mg
See related: EnsemblRapid:ENSXLAG00005021121 AllianceGenome:Xenbase:XB-GENE-961235
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ndufs1
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity, acting on NAD(P)H. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (91400047..91419939, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10L	NC_030740.1 (80817422..80837313, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase (ubiquinone) activity	IEA Inferred from Electronic Annotation more info
enables NADH dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular respiration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADH:ubiquinone oxidoreductase core subunit S1 L homeolog

Names: NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086839.1 → NP_001080308.1 NADH:ubiquinone oxidoreductase core subunit S1 L homeolog

See identical proteins and their annotated locations for NP_001080308.1

Status: PROVISIONAL

Source sequence(s)

BC049394

UniProtKB/TrEMBL

A0A974BZT7, Q802B7

Related

ENSXLAP00005061979.1, ENSXLAT00005063432.1

Conserved Domains (5) summary

smart00929
Location:113 → 153

NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region

PRK09130
Location:31 → 723

PRK09130; NADH dehydrogenase subunit G; Validated

cd02773
Location:249 → 630

MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...

pfam09326
Location:678 → 710

NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal

pfam13510
Location:29 → 107

Fer2_4; 2Fe-2S iron-sulfur cluster binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

91400047..91419939 complement

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GenBank, FASTA, Sequence Viewer (Graphics)