sh2d3c.L SH2 domain containing 3C L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sh2d3c.L
Official Full Name: SH2 domain containing 3C L homeolog
Primary source: Xenbase:XB-GENE-6254468
Locus tag: XELAEV_18004135mg
See related: EnsemblRapid:ENSXLAG00005020707 AllianceGenome:Xenbase:XB-GENE-6254468
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sh2d3c; pro34088
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to act upstream of or within positive regulation of peptidyl-serine phosphorylation and small GTPase-mediated signal transduction. Is expressed in ectoderm; nervous system; and visual system. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (14859971..14901794, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694861.1 (796022..810204)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH2 domain-containing protein 3C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086827.1 → NP_001080296.1 SH2 domain-containing protein 3C

See identical proteins and their annotated locations for NP_001080296.1

Status: PROVISIONAL

Source sequence(s)

BC041733

UniProtKB/TrEMBL

A0A974BS58, Q8AVM4

Related

ENSXLAP00005060798.1, ENSXLAT00005062250.1

Conserved Domains (2) summary

cd10337
Location:32 → 165

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:401 → 669

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

14859971..14901794 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041571910.1 → XP_041427844.1 SH2 domain-containing protein 3C isoform X1

UniProtKB/TrEMBL

A0A8J1LFP5

Related

ENSXLAP00005060829.1, ENSXLAT00005062281.1

Conserved Domains (2) summary

cd10337
Location:227 → 360

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:596 → 864

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
XM_041571911.1 → XP_041427845.1 SH2 domain-containing protein 3C isoform X2

UniProtKB/TrEMBL

A0A8J1LGN1, A0A974H5D6

Related

ENSXLAP00005060806.1, ENSXLAT00005062258.1

Conserved Domains (2) summary

cd10337
Location:135 → 268

SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3

cl02485
Location:504 → 772

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...