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gns.S glucosamine (N-acetyl)-6-sulfatase S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379953, updated on 4-Nov-2024

Summary

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Official Symbol
gns.S
Official Full Name
glucosamine (N-acetyl)-6-sulfatase S homeolog
Primary source
Xenbase:XB-GENE-978433
Locus tag
XELAEV_18021194mg
See related
EnsemblRapid:ENSXLAG00005020670 AllianceGenome:Xenbase:XB-GENE-978433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gns
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and metal ion binding activity. Predicted to act upstream of or within glycosaminoglycan metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gns.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (89959801..89993853, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (88125379..88159439, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 3 S homeolog Neighboring gene adipocyte plasma membrane-associated protein-like Neighboring gene U5 spliceosomal RNA Neighboring gene TBC1 domain family member 30 S homeolog Neighboring gene WNT inhibitory factor 1 S homeolog Neighboring gene LEM domain containing 3 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53439

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycosaminoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucosamine (N-acetyl)-6-sulfatase S homeolog
Names
glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)
NP_001080261.1
XP_018109551.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086792.1 → NP_001080261.1  glucosamine (N-acetyl)-6-sulfatase S homeolog

    See identical proteins and their annotated locations for NP_001080261.1

    Status: PROVISIONAL

    Source sequence(s)
    BC042274
    UniProtKB/TrEMBL
    A0A974HRD6, Q8AVH8
    Related
    ENSXLAP00005060621.1, ENSXLAT00005062070.1
    Conserved Domains (2) summary
    COG3119
    Location:40 → 505
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16147
    Location:42 → 490
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    89959801..89993853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018254062.2 → XP_018109551.1  glucosamine (N-acetyl)-6-sulfatase S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UU68, A0A974HRD6
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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