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dnm1l.L dynamin 1-like L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379875, updated on 4-Nov-2024

Summary

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Official Symbol
dnm1l.L
Official Full Name
dynamin 1-like L homeolog
Primary source
Xenbase:XB-GENE-487283
Locus tag
XELAEV_18016698mg
See related
EnsemblRapid:ENSXLAG00005009613 AllianceGenome:Xenbase:XB-GENE-487283
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dnm1l; dnm1l.S
Summary
Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Predicted to act upstream of or within mitochondrial fission; mitochondrial fragmentation involved in apoptotic process; and rhythmic process. Predicted to be located in several cellular components, including bounding membrane of organelle; clathrin-coated pit; and peroxisome. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dnm1l.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (3974883..4009196, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (3630823..3665159, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene cysteine rich, DPF motif domain containing 1 L homeolog Neighboring gene tyrosine--tRNA ligase, mitochondrial-like Neighboring gene tetratricopeptide repeat domain 38 L homeolog Neighboring gene FYVE, RhoGEF and PH domain containing 4 L homeolog Neighboring gene BICD cargo adaptor 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53850

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial fragmentation involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynamin 1-like L homeolog
Names
dynamin 1-like S homeolog
NP_001080183.1
XP_041440882.1
XP_041440883.1
XP_041440884.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086714.1 → NP_001080183.1  dynamin 1-like L homeolog

    See identical proteins and their annotated locations for NP_001080183.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046374
    UniProtKB/TrEMBL
    A0A974D8F8, Q7ZWZ9
    Related
    ENSXLAP00005028786.1, ENSXLAT00005029526.1
    Conserved Domains (4) summary
    cd08771
    Location:23 → 302
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:88 → 691
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    pfam01031
    Location:227 → 510
    Dynamin_M; Dynamin central region
    pfam02212
    Location:604 → 692
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    3974883..4009196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041584949.1 → XP_041440883.1  dynamin 1-like L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J1MH85, A0A974D8F8
    Related
    ENSXLAP00005028783.1, ENSXLAT00005029523.1
    Conserved Domains (2) summary
    cd08771
    Location:23 → 302
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:88 → 714
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

  2. XM_041584950.1 → XP_041440884.1  dynamin 1-like L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1MGP1, A0A974D8F8
    Conserved Domains (2) summary
    cd08771
    Location:23 → 315
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:101 → 704
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

  3. XM_041584948.1 → XP_041440882.1  dynamin 1-like L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MGP2, A0A974D8F8
    Related
    ENSXLAP00005028765.1, ENSXLAT00005029505.1
    Conserved Domains (2) summary
    cd08771
    Location:23 → 315
    DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
    COG0699
    Location:101 → 727
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version

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