ran.S RAN, member RAS oncogene family S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ran.S
Official Full Name: RAN, member RAS oncogene family S homeolog
Primary source: Xenbase:XB-GENE-865870
Locus tag: XELAEV_18010576mg
See related: EnsemblRapid:ENSXLAG00005008203 AllianceGenome:Xenbase:XB-GENE-865870
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ran; tc4; Xran; gsp1; ara24; ran-1; RanTC4
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to act upstream of or within protein import into nucleus and ribosomal subunit export from nucleus. Predicted to be located in cytoplasm and nuclear envelope. Is expressed in ectoderm; mesenchyme; musculoskeletal system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1S

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1S	NC_054372.1 (146486448..146498056, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1S	NC_030725.1 (130745095..130756704, complement)

Chromosome 1S - NC_054372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Augmin is a Ran-regulated spindle assembly factor.
Title: Augmin is a Ran-regulated spindle assembly factor.
meiosis II spindle assembly did not tolerate changes in the level of RanGTP
Title: A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosomal subunit export from nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP-binding nuclear protein Ran

Names: GTPase Ran; ran GTP-binding protein; ras-like protein TC4; ras-related nuclear protein

NP_001080182.1

EC 3.6.5.-

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_018089010.1

EC 3.6.5.-

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

XP_018089018.1

EC 3.6.5.-

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086713.1 → NP_001080182.1 GTP-binding nuclear protein Ran

See identical proteins and their annotated locations for NP_001080182.1

Status: PROVISIONAL

Source sequence(s)

BC041293

UniProtKB/TrEMBL

A0A974I1X2

Conserved Domains (2) summary

cd00877
Location:11 → 176

Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases

PTZ00132
Location:1 → 216

PTZ00132; GTP-binding nuclear protein Ran; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

146486448..146498056 complement

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GenBank, FASTA, Sequence Viewer (Graphics)