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eif2b3.L eukaryotic translation initiation factor 2B subunit gamma L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379837, updated on 4-Nov-2024

Summary

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Official Symbol
eif2b3.L
Official Full Name
eukaryotic translation initiation factor 2B subunit gamma L homeolog
Primary source
Xenbase:XB-GENE-961439
Locus tag
XELAEV_18023084mg
See related
EnsemblRapid:ENSXLAG00005026531 AllianceGenome:Xenbase:XB-GENE-961439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
eif2b3
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to act upstream of or within cytoplasmic translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 3. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eif2b3.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
14
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (85658025..85687304)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (80363512..80390034)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene testis associated actin remodelling kinase 2 L homeolog Neighboring gene uncharacterized LOC108714273 Neighboring gene patched 2 L homeolog Neighboring gene BTB/POZ domain-containing protein 19-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC52809

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 2B complex IEA
Inferred from Electronic Annotation
more info
  
part_of guanyl-nucleotide exchange factor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2B, subunit 3 gamma
Names
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086676.1 → NP_001080145.2  eukaryotic translation initiation factor 2B, subunit 3 gamma

    Status: VALIDATED

    Source sequence(s)
    BC041256
    UniProtKB/TrEMBL
    A0A1L8GM44, A0A974D3H5, Q8AVU8
    Related
    ENSXLAP00005078831.1, ENSXLAT00005080422.1
    Conserved Domains (2) summary
    cd04198
    Location:5 → 217
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:4 → 435
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    85658025..85687304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589153.1 → XP_041445087.1  eukaryotic translation initiation factor 2B, subunit 3 gamma isoform X2

    UniProtKB/TrEMBL
    A0A1L8GM44, A0A974D3H5, Q8AVU8
    Conserved Domains (2) summary
    cd04198
    Location:5 → 217
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:4 → 435
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

  2. XM_041589152.1 → XP_041445086.1  eukaryotic translation initiation factor 2B, subunit 3 gamma isoform X2

    UniProtKB/TrEMBL
    A0A1L8GM44, A0A974D3H5, Q8AVU8
    Related
    ENSXLAP00005078934.1, ENSXLAT00005080525.1
    Conserved Domains (2) summary
    cd04198
    Location:5 → 217
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:4 → 435
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

  3. XM_041589151.1 → XP_041445085.1  eukaryotic translation initiation factor 2B, subunit 3 gamma isoform X1

    UniProtKB/TrEMBL
    A0A8J1MVN3, Q8AVU8
    Related
    ENSXLAP00005079004.1, ENSXLAT00005080595.1
    Conserved Domains (2) summary
    cd04198
    Location:9 → 221
    eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    COG1208
    Location:8 → 439
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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