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ppp2r1a.L protein phosphatase 2 regulatory subunit A, alpha L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379827, updated on 4-Nov-2024

Summary

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Official Symbol
ppp2r1a.L
Official Full Name
protein phosphatase 2 regulatory subunit A, alpha L homeolog
Primary source
Xenbase:XB-GENE-990852
Locus tag
XELAEV_18036294mg
See related
EnsemblRapid:ENSXLAG00005013673 AllianceGenome:Xenbase:XB-GENE-990852
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pr65a; ppp2r1a; ppp2r1a-a; ppp2r1a-b; pp2aaalpha; pp2a-aalpha
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to act upstream of or within chromosome segregation and protein dephosphorylation. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 2A complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ppp2r1a.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
15
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (128575094..128604001, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (116617605..116646627, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene chemokine-like receptor 1 Neighboring gene probable G-protein coupled receptor 33 Neighboring gene probable G-protein coupled receptor 33 Neighboring gene sialic acid-binding Ig-like lectin 8 Neighboring gene sialic acid-binding Ig-like lectin 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC53746

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 2 regulatory subunit A, alpha L homeolog
Names
protein phosphatase 2, regulatory subunit A, alpha
NP_001080135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086666.1 → NP_001080135.1  protein phosphatase 2 regulatory subunit A, alpha L homeolog

    See identical proteins and their annotated locations for NP_001080135.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046723
    UniProtKB/TrEMBL
    A0A974CH60, Q7ZWS7
    Related
    ENSXLAP00005040513.1, ENSXLAT00005041436.1
    Conserved Domains (4) summary
    pfam13513
    Location:179 → 231
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:488 → 583
    HEAT_2; HEAT repeats
    sd00044
    Location:245 → 269
    HEAT; HEAT repeat [structural motif]
    cl21454
    Location:396 → 454
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    128575094..128604001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials