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pdk4.L pyruvate dehydrogenase kinase 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379789, updated on 4-Nov-2024

Summary

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Official Symbol
pdk4.L
Official Full Name
pyruvate dehydrogenase kinase 4 L homeolog
Primary source
Xenbase:XB-GENE-866081
Locus tag
XELAEV_18030882mg
See related
EnsemblRapid:ENSXLAG00005029303 AllianceGenome:Xenbase:XB-GENE-866081
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
PDKe; PDKk; pdk4; 3j828; xPDKe; xPDKk
Summary
Predicted to enable ATP binding activity and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to act upstream of or within protein phosphorylation and regulation of glucose metabolic process. Predicted to be located in mitochondrial matrix. Is expressed in ectoderm; nervous system; and visual system. Orthologous to human PDK4 (pyruvate dehydrogenase kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pdk4.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (33145682..33161879, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (30670402..30686782, complement)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene serum paraoxonase/arylesterase 2-like Neighboring gene paraoxonase 2 L homeolog Neighboring gene cytoplasmic dynein 1 intermediate chain 1 Neighboring gene solute carrier family 25 member 13 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC52849, MGC132353

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase kinase 2
Names
pyruvate dehydrogenase kinase, isoenzyme 2
pyruvate dehydrogenase kinase, isozyme 4
NP_001080097.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086628.1 → NP_001080097.1  pyruvate dehydrogenase kinase 2

    See identical proteins and their annotated locations for NP_001080097.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044112
    UniProtKB/TrEMBL
    A0A974CLP9, Q7ZXU6
    Related
    ENSXLAP00005087615.1, ENSXLAT00005089277.1
    Conserved Domains (3) summary
    smart00387
    Location:242 → 362
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:198 → 370
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    33145682..33161879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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