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calr.S calreticulin homeolog S [ Xenopus laevis (African clawed frog) ]

Gene ID: 379788, updated on 4-Nov-2024

Summary

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Official Symbol
calr.S
Official Full Name
calreticulin homeolog S
Primary source
Xenbase:XB-GENE-1018219
Locus tag
XELAEV_18000414mg
See related
EnsemblRapid:ENSXLAG00005010461 AllianceGenome:Xenbase:XB-GENE-1018219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
crc; crt; calr; comp28
Summary
Predicted to enable calcium ion binding activity and unfolded protein binding activity. Predicted to act upstream of or within protein folding. Predicted to be located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See calr.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (124860255..124869196, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694811.1 (1314445..1323339, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016708729.1 (236..828, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene growth arrest and DNA damage-inducible proteins-interacting protein 1 S homeolog Neighboring gene tetratricopeptide repeat domain 39A like S homeolog Neighboring gene phenylalanyl-tRNA synthetase subunit alpha S homeolog Neighboring gene uncharacterized LOC121402280

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An atlas of differential gene expression during early Xenopus embryogenesis. Pollet N, et al. Mech Dev, 2005 Mar. PMID 15763213
  2. Axeldb: a Xenopus laevis database focusing on gene expression. Pollet N, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592204, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC52637

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calreticulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086627.1 → NP_001080096.1  calreticulin precursor

    See identical proteins and their annotated locations for NP_001080096.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044068
    UniProtKB/TrEMBL
    Q7ZXY3, Q91710
    Related
    ENSXLAP00005030845.1, ENSXLAT00005031610.1
    Conserved Domains (1) summary
    pfam00262
    Location:24 → 332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    124860255..124869196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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