cdk1.L cyclin-dependent kinase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cdk1.L
Official Full Name: cyclin-dependent kinase 1 L homeolog
Primary source: Xenbase:XB-GENE-6254942
Locus tag: XELAEV_18034469mg
See related: EnsemblRapid:ENSXLAG00005011687 AllianceGenome:Xenbase:XB-GENE-6254942
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: MPF; cdc2; cdk1; cdc-2; cdc2a; xcdc2; PSTAIR; cdc2-b; cdc28a; cdk1-a; cdk1-b; p34cdc2; cdc2x1.1; cdc2x1.2
Summary: Enables protein serine/threonine kinase activity. Predicted to act upstream of or within G2/M transition of mitotic cell cycle and regulation of circadian rhythm. Predicted to be located in cytosol. Is expressed in cardiovascular system; ectoderm; mesenchyme; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (11392721..11403478)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (11430883..11441727)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
Title: CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets.
Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.
Title: Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-dependent kinase 1-B

Names: cell division control protein 2 homolog 2; cell division control protein 2-B; cell division cycle 2 homolog A; cell division protein kinase 1; cell division protein kinase 1-B; maturation-promoting factor; p34 protein kinase 2

NP_001080093.1

EC 2.7.11.22

EC 2.7.11.23

XP_018079784.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086624.1 → NP_001080093.1 cyclin-dependent kinase 1-B

See identical proteins and their annotated locations for NP_001080093.1

Status: PROVISIONAL

Source sequence(s)

BC054146

UniProtKB/Swiss-Prot

P24033, Q7SZ44

UniProtKB/TrEMBL

A0A974HB46

Related

ENSXLAP00005034105.1, ENSXLAT00005034988.1

Conserved Domains (2) summary

PLN00009
Location:1 → 290

PLN00009; cyclin-dependent kinase A; Provisional

cd07861
Location:3 → 287

STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes