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snrpa.S small nuclear ribonucleoprotein polypeptide A S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379781, updated on 4-Nov-2024

Summary

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Official Symbol
snrpa.S
Official Full Name
small nuclear ribonucleoprotein polypeptide A S homeolog
Primary source
Xenbase:XB-GENE-6254943
Locus tag
XELAEV_18042532mg
See related
EnsemblRapid:ENSXLAG00005008694 AllianceGenome:Xenbase:XB-GENE-6254943
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
U1A; snf; mud1; snrpa
Summary
Predicted to enable U1 snRNA binding activity. Predicted to act upstream of or within mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA (small nuclear ribonucleoprotein polypeptide A). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See snrpa.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
7
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (84600197..84609126)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (82221414..82230341)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase C S homeolog Neighboring gene actin maturation protease S homeolog Neighboring gene ras homolog family member U S homeolog Neighboring gene serine/threonine-protein kinase dst1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding. Scherly D, et al. J Mol Biol, 1991 Jun 20. PMID 1829114
  2. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Piazzon N, et al. Nucleic Acids Res, 2013 Jan. PMID 23221635, Free PMC Article
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC52976

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of U1 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small nuclear ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U1 small nuclear ribonucleoprotein A
Names
U1 snRNP A
U1 snRNP protein A
U1-A
sans fille

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086620.1 → NP_001080089.1  U1 small nuclear ribonucleoprotein A

    See identical proteins and their annotated locations for NP_001080089.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044979
    UniProtKB/Swiss-Prot
    P45429
    UniProtKB/TrEMBL
    A0A974H632, Q7ZXI5
    Related
    ENSXLAP00005025241.1, ENSXLAT00005025950.1
    Conserved Domains (3) summary
    COG0724
    Location:1 → 108
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12477
    Location:7 → 95
    RRM1_U1A; RNA recognition motif 1 found in vertebrate U1 small nuclear ribonucleoprotein A (U1A)
    cd12480
    Location:203 → 282
    RRM2_U1A; RNA recognition motif 2 found in vertebrate U1 small nuclear ribonucleoprotein A (U1 snRNP A or U1-A or U1A)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    84600197..84609126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45429.1 GenPept UniProtKB/Swiss-Prot:P45429

Gene LinkOut

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