lmnb1.L lamin B1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lmnb1.L
Official Full Name: lamin B1 L homeolog
Primary source: Xenbase:XB-GENE-489662
Locus tag: XELAEV_18007951mg
See related: EnsemblRapid:ENSXLAG00005035110 AllianceGenome:Xenbase:XB-GENE-489662
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: lmnb1; lamin-b; Lamin-L(I)
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to act upstream of or within several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in intermediate filament; nuclear envelope; and nuclear lamina. Is expressed in visual system. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (182620038..182641609, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (169469959..169491631, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly.
Title: Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within heterochromatin formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear pore localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to nuclear envelope	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lamin B1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086584.1 → NP_001080053.1 lamin B1 L homeolog

See identical proteins and their annotated locations for NP_001080053.1

Status: PROVISIONAL

Source sequence(s)

BC041185

UniProtKB/TrEMBL

A0A974E1P6, O93398, Q8AVZ3

Related

ENSXLAP00005105096.1, ENSXLAT00005107140.1

Conserved Domains (2) summary

pfam00038
Location:31 → 387

Filament; Intermediate filament protein

pfam00932
Location:435 → 543

LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

182620038..182641609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)