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KIF3C kinesin family member 3C [ Homo sapiens (human) ]

Gene ID: 3797, updated on 2-Nov-2024

Summary

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Official Symbol
KIF3Cprovided by HGNC
Official Full Name
kinesin family member 3Cprovided by HGNC
Primary source
HGNC:HGNC:6321
See related
Ensembl:ENSG00000084731 MIM:602845; AllianceGenome:HGNC:6321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule cytoskeleton; neuronal cell body; and neuronal ribonucleoprotein granule. Predicted to be part of kinesin complex. Predicted to be active in microtubule. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 57.3), adrenal (RPKM 4.3) and 1 other tissue See more
Orthologs
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Genomic context

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See KIF3C in Genome Data Viewer
Location:
2p23.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (25926598..25982497, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (25961945..26017861, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26149467..26205366, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASXL transcriptional regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15465 Neighboring gene Sharpr-MPRA regulatory region 10168 Neighboring gene prostaglandin E synthase 3 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26083605-26084105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11264 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26202609-26203118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26203119-26203627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204137-26204645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:26204646-26205155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11267 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234163-26234664 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:26234665-26235164 Neighboring gene ubiquinol-cytochrome c reductase hinge protein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:26251416-26251944 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling. Wang C, et al. Cancer Lett, 2015 Nov 1. PMID 26272184
  2. KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway. Gao Y, et al. J Neurooncol, 2020 Feb. PMID 32020481
  3. Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis. Chen J, et al. Int J Oral Sci, 2023 Sep 26. PMID 37752101, Free PMC Article
  4. KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT. Gao Y, et al. Biomed Res Int, 2020. PMID 33150178, Free PMC Article
  5. KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23. Sardella M, et al. Genomics, 1998 Feb 1. PMID 9480755

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
    Title: Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
  2. Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
    Title: Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
  3. KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
    Title: KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
  4. KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
    Title: KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
  5. Results suggest that high expression of KIF3C in breast cancer may be associated with tumor progression and metastasis.
    Title: Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling.
  6. FMRP acts also as a molecular adaptor between RNA granules and the neurospecific kinesin KIF3C.
    Title: The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of kinesin family member 3C (KIF3C) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal motor activity TAS
Traceable Author Statement
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in ciliary tip TAS
Traceable Author Statement
more info
  
located_in cilium TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF3C
Names
KIF3C variant protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002254.8 → NP_002245.4  kinesin-like protein KIF3C

    See identical proteins and their annotated locations for NP_002245.4

    Status: VALIDATED

    Source sequence(s)
    AC013449, AC064847, KF456639
    Consensus CDS
    CCDS1719.1
    UniProtKB/Swiss-Prot
    O14782, O43544, Q4ZG18, Q53SX5, Q562F7
    UniProtKB/TrEMBL
    A2RU78, B7ZM25, Q7Z2W5
    Related
    ENSP00000264712.3, ENST00000264712.8
    Conserved Domains (4) summary
    cd01371
    Location:9 → 365
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:16 → 365
    Kinesin; Kinesin motor domain
    cd16269
    Location:538 → 549
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:461 → 569
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    25926598..25982497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264299.4 → XP_005264356.2  kinesin-like protein KIF3C isoform X1

    UniProtKB/TrEMBL
    B7ZM25
    Conserved Domains (4) summary
    cd01371
    Location:9 → 365
    KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
    pfam00225
    Location:16 → 365
    Kinesin; Kinesin motor domain
    cd16269
    Location:538 → 549
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:461 → 569
    GBP_C; Guanylate-binding protein, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    25961945..26017861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341956.1 → XP_054197931.1  kinesin-like protein KIF3C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14782.4 GenPept UniProtKB/Swiss-Prot:O14782

Gene LinkOut

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