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slc32a1.S solute carrier family 32 member 1 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379652, updated on 4-Nov-2024

Summary

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Official Symbol
slc32a1.S
Official Full Name
solute carrier family 32 member 1 S homeolog
Primary source
Xenbase:XB-GENE-865905
Locus tag
XELAEV_18046597mg
See related
EnsemblRapid:ENSXLAG00005035929 AllianceGenome:Xenbase:XB-GENE-865905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
vgat; viaat
Summary
Predicted to enable gamma-aminobutyric acid:proton antiporter activity and glycine:proton antiporter activity. Predicted to act upstream of or within beta-alanine transport; gamma-aminobutyric acid import; and glycine transport. Predicted to be located in synaptic vesicle. Is expressed in nervous system and visual system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See slc32a1.S in Genome Data Viewer
Location:
chromosome: 9_10S
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (34378002..34394953, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (28866449..28881201, complement)

Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121399185 Neighboring gene protein tyrosine phosphatase receptor type T S homeolog Neighboring gene Rho GTPase activating protein 40 S homeolog Neighboring gene ARP5 actin related protein 5 homolog S homeolog Neighboring gene protein phosphatase 1 regulatory subunit 16B S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression patterns of glycine transporters (xGlyT1, xGlyT2, and xVIAAT) in Xenopus laevis during early development. Wester MR, et al. Gene Expr Patterns, 2008 Apr. PMID 18262473
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The spatial and temporal expression patterns of xVIAAT during early developmental stages of Xenopus laevis.
    Title: Expression patterns of glycine transporters (xGlyT1, xGlyT2, and xVIAAT) in Xenopus laevis during early development.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC68938

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables gamma-aminobutyric acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gamma-aminobutyric acid:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycine:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within beta-alanine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid import ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glycine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vesicular inhibitory amino acid transporter
Names
GABA and glycine transporter
slc32a1
solute carrier family 32 (GABA vesicular transporter), member 1 S homeolog
vesicular GABA transporter
xVIAAT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086492.1 → NP_001079961.1  vesicular inhibitory amino acid transporter

    See identical proteins and their annotated locations for NP_001079961.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057733
    UniProtKB/Swiss-Prot
    Q6PF45
    UniProtKB/TrEMBL
    A0A1L8EMI6, A0A974H0Q1
    Related
    ENSXLAP00005107413.1, ENSXLAT00005109541.1
    Conserved Domains (1) summary
    pfam01490
    Location:108 → 505
    Aa_trans; Transmembrane amino acid transporter protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    34378002..34394953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041577628.1 → XP_041433562.1  vesicular inhibitory amino acid transporter isoform X1

    UniProtKB/Swiss-Prot
    Q6PF45
    UniProtKB/TrEMBL
    A0A1L8EMI6, A0A974H0Q1
    Conserved Domains (1) summary
    pfam01490
    Location:108 → 505
    Aa_trans; Transmembrane amino acid transporter protein

  2. XM_041577627.1 → XP_041433561.1  vesicular inhibitory amino acid transporter isoform X1

    UniProtKB/Swiss-Prot
    Q6PF45
    UniProtKB/TrEMBL
    A0A1L8EMI6, A0A974H0Q1
    Conserved Domains (1) summary
    pfam01490
    Location:108 → 505
    Aa_trans; Transmembrane amino acid transporter protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PF45.1 GenPept UniProtKB/Swiss-Prot:Q6PF45

Gene LinkOut

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Molecular Biology Databases
Research Materials