pck1.S phosphoenolpyruvate carboxykinase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pck1.S
Official Full Name: phosphoenolpyruvate carboxykinase 1 S homeolog
Primary source: Xenbase:XB-GENE-1009237
Locus tag: XELAEV_18046218mg
See related: EnsemblRapid:ENSXLAG00005030774 AllianceGenome:Xenbase:XB-GENE-1009237
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pck1; pepck1; pepckc; pepck-c
Summary: Predicted to enable several functions, including GTP binding activity; manganese ion binding activity; and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to act upstream of or within several processes, including carboxylic acid metabolic process; cellular response to dexamethasone stimulus; and gluconeogenesis. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (12736233..12741566)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (12630229..12635562)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoenolpyruvate carboxykinase (GTP) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dicarboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycerol biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hepatocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within propionate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to starvation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoenolpyruvate carboxykinase 1 S homeolog

Names: phosphoenolpyruvate carboxykinase 1 (soluble)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086477.1 → NP_001079946.1 phosphoenolpyruvate carboxykinase 1 S homeolog

See identical proteins and their annotated locations for NP_001079946.1

Status: PROVISIONAL

Source sequence(s)

BC057715

UniProtKB/TrEMBL

A0A974H0N9, Q6PF62

Related

ENSXLAP00005092158.1, ENSXLAT00005093841.1

Conserved Domains (1) summary

cd00819
Location:27 → 615

PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...